An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Removal performance of SARS-CoV-2 in wastewater treatment by membrane bioreactor, anaerobic-anoxic-oxic, and conventional activated sludge processesArticle Published on 2022-12-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activated applicability CAS chlorination collected COVID-19 outbreak Detection limit evaluate Final fraction independent influent investigated Japan log Log reduction Log reduction value (LRV) lowest membrane Membrane bioreactor (MBR) Mild Pepper mild mottle virus (PMMoV) potential risk quantified reduction removal RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA significantly lower treated Treatment virus wastewater Wastewater treatment plant (WWTP). [DOI] 10.1016/j.scitotenv.2022.158310 PMC 바로가기
Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic healthArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 진단, [키워드] affected cardiometabolic cardiovascular Cluster Complication country COVID COVID-19 COVID-19 pandemic COVID-19 severity CVD cytokine cytokine production diabetes Final hallmark Health hypertension IL-6 IL10 IL2 IL4 IL8 immune system increased the risk infected patient Inflammation inflammatory state influence molecular molecular. morbidity and mortality obese pathophysiological Patient predictor pro-inflammatory reported resulting SARS-CoV2 systemic damage target type 2 diabete virus [DOI] 10.1016/j.bbadis.2022.166559 PMC 바로가기
Sensitive detection of SARS-CoV-2 molecular markers in urban community sewersheds using automated viral RNA purification and digital droplet PCRArticle Published on 2022-11-152022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] affecting approach automated Care Community correlation COVID-19 COVID-19 case detection of marker Detroit disadvantage Effectiveness Epidemiology faster Final handling Health identify inhibitor Local marker molecular number of sample outbreak PCR PerkinElmer Prevent Promega public health authority purification required RNA RNA purification SARS-CoV-2 sensitive sensitivity Standard state the SARS-CoV-2 virus Thermofisher time-consuming Viral RNA Volume wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157547 PMC 바로가기
Fear learning and generalization during pandemic fear: How COVID-19-related anxiety affects classical fear conditioning with traumatic film clipsResearch article Published on 2022-11-012022-10-05 Journal: Journal of psychiatric research [Category] 바이오마커, 임상, 치료기술, [키워드] acquisition Affect Anxiety anxiety disorders classical clinical trial collected conditioned connection contribute COVID-19 COVID-19 pandemic Effect expected experiment fear Fear conditioning Fear generalization Final greater Health healthy higher risk impairment increase in investigated mechanism pandemic Pandemic fear participant Psychological well-being recent risk factor significantly Stress Symptom [DOI] 10.1016/j.jpsychires.2022.07.068 [Article Type] Research article
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Respiratory Medicine [Category] SARS, 변종, 치료기술, [키워드] accelerate Alpha assessment assumption Bayesian Cohort cohort study Community Contact correlation Course COVID-19 COVID-19 case determine diagnosed early diagnosis eight eligible enrolled Evidence Final Guidance Hierarchical High-resolution household index cases Infection infection control Infectious virus initial IQR Isolation kinetic Lateral flow device LFD median Older Onset participant PCR positive PCR-confirmed plaque-forming unit post-symptom onset Probability quantified real-world data recruitment reduced released RT-PCR SARS-CoV-2 Self-isolation sensitivity Seven study population suggested Support survival Symptom symptom onset Symptoms the median the SARS-CoV-2 to define Transmission upper respiratory tract variant viral growth Viral load viral replication Viral RNA viral RNA load viral shedding virus were assessed [DOI] 10.1016/S2213-2600(22)00226-0 PMC 바로가기
Fate of SARS-CoV-2 coronavirus in wastewater treatment sludge during storage and thermophilic anaerobic digestionArticle Published on 2022-11-012022-11-15 Journal: Environmental research [Category] SARS, 치료기술, [키워드] addition ambient anaerobic Bovine coronavirus conducted COVID-19 outbreak Detection limit digestion droplet droplet digital PCR Final inactivated knowledge Laboratory Max 6) other coronaviruses Particle PCR question raised reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 detection SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 stability Sludge Stability. Stool stools temperature Treatment virus were used [DOI] 10.1016/j.envres.2022.114057 PMC 바로가기
Concordance of B- and T-cell responses to SARS-CoV-2 infection, irrespective of symptoms suggestive of COVID-19Article Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, [키워드] absence Analysis anti-IgG antibodies antibody Antibody titer Cellular immune response cellular immunity Cohort correlated correlated strongly COVID COVID-19 COVID-19 pandemic ELISA Evidence Final First wave IgG individual pandemic participant positive antibody response Regulatory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV2 infection spike Symptom symptom response. symptomatic and asymptomatic T cell T-cell T-cell Response TwinsUK were assessed [DOI] 10.1002/jmv.28016 PMC 바로가기
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody CombinationArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] antibodies antibody applicability approach binding capture reagent clinical analysis Combination complementarity-determining region conditions coronavirus disease Critical demonstrated domain extension Final hybrid implementation Infection Ligand limit lining mAb macromolecules Magnetic beads matrix effect monoclonal antibody multidimensional nasal offer patient population peptide performed platform quantification reagent reagents reproducibility required sensitivity serum significantly Tandem mass spectrometry Treatment vaccination viral spike protein [DOI] 10.1021/acs.analchem.2c01320 PMC 바로가기
Covid-MANet: Multi-task attention network for explainable diagnosis and severity assessment of COVID-19 from CXR imagesResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 진단, 치료기술, [키워드] Accuracy approach approach assigned automated Bacterial chest X-ray CNN conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 diagnosis COVID-19 disease COVID-19 infection Critical CXR dataset deep learning develop Diagnosis disease early diagnosis eight experiment Explainable AI False negative Final first stage Health highlight IMPROVE Infection Infection Segmentation initial Interpretation lung Lung segmentation Lungs measure Mild moderate outbreak outperform Pneumonia predicted proportion quantification radiological examination reduced Region reported Research research finding RT-PCR test scoring system sensitivity sensitivity analysis severity severity of COVID-19 Stage Support transfer learning Tuberculosis Viral pneumonia with COVID-19 [DOI] 10.1016/j.patcog.2022.108826 [Article Type] Research article